Dr. Anan cited research explaining the cause of COVID-19, the BA.2.75 strain being the main strain instead of BA.5.
on November 18 Dr. Anant Chongkaewwatana Biotech virology researcher reveals on Facebook Anan Jongkaewwattana along with attaching research that indicates the situation of COVID-19 by saying that it matches the situation in Thailand
Dr. Anan stated that This research came out to match the situation in Thailand. I was wondering why BA.2.75 was the main strain to replace BA.5 despite the results of several laboratory tests that this strain of virus did not have immune escape properties from the vaccine. Or a natural landscape that is outstanding like other species
The results of this study showed that BA.2.75 was remarkable for its ability to bind to ACE2 receptor proteins on the cell surface 9 times better than the original BA.2, which could explain that escaping the immune system might not be very good. But it binds well to cells and can become a main strain of the virus. Using escape ability alone may not be enough to predict the direction of the virus to adapt itself.
Viruses that will become the dominant strain in nature seek to strike a balance between their ability to bind to receptor proteins. and the ability to escape the landscape to a reasonable level Which one is in the perfect position is probably the most suitable one in nature.
If you look at the graph that compares both the landscape escape And the ability to bind to ACE2 proteins, the most noteworthy now is the BN.1 group because it binds to ACE2 at the same level as BA.2.75, but is significantly better at escaping.
